Detergent Industry Network for CLP Classification

How does it work ?

In practice, a company and its nominated expert(s) will go through the following steps:

Flowchart of steps to join the Detergent Industry Network: sign up, nominate expert, log in, classify mixture, apply CLP principles, label, and update SDS.

Download the Steps on-page overview

Experts

The DetNet database can be used by classification experts nominated by a company or by one of the external experts.

The role of an expert is to:

  • Undertake training prior to the use of the DetNet database and demonstrate competency in application of the classification approach;
  • Use the classification explanatory notes developed by A.I.S.E. to classify detergent and cleaning products for skin and eye irritation/corrosion;
  • Compare the composition of the untested mixture to the reference formulations included in DetNet database and select the most appropriate ones for classification purposes, as applicable;
  • Complete the agreed level of documentation to support classification decisions;
  • Refer issues, inadequacies or problems with the guidance and gaps in the DetNet database to the DetNet manager (This email address is being protected from spambots. You need JavaScript enabled to view it.);
  • Discuss and explain classification decisions with national authorities when required - such issues are to be notified to DetNet manager (This email address is being protected from spambots. You need JavaScript enabled to view it.) which will provide support as necessary.

For more information on experts click here.

 

Scientific Advisory Panel

The Scientific Advisory Panel (SAP) comprises recognised independent experts in the fields of toxicology, dermatology or ophthalmology who have been working with A.I.S.E. to ensure that DetNet is a robust and relevant means of correctly classify detergent and cleaning products.

SAP members act and decide independently and solely on the basis of scientific considerations, under full confidentiality.

The role of the SAP under DetNet is to provide advice to A.I.S.E. on the scientific approach, toxicological assessment, clinical experience and generation of reliable data (for classification purposes).

 

DetNet database

The DetNet database includes ca. 200 formulations ('Reference Formulations'), covering a wide range of market relevant mixtures, each supported by skin and/or eye toxicological test data, either historical in vivo or data generated using in vitro methods.

The DetNet database provides a Reference Formulation Search Tool which allows identifying potential reference formulations for further evaluation. The reference formulations include laundry detergents (liquids and powders), hand dish wash detergents and all-purpose cleaners.

For each reference formulation the compositional details, the physical-chemical data and the toxicological summary of associated test data are available. Reference Formulation compositions are made available to experts from companies using a fixed format that provides sufficient detail to enable comparison of mixtures and application of bridging 

principles, but still protects confidential business information of the data owner (e.g. no trade name of ingredient, use ‘perfume’ generically, etc.)

Toxicological data of Reference Formulations include in vitro data (generated using validated in vitro test methods, such as the EpiSkinTM Skin Irritation Test, and the Isolated Chicken Eye Test enhanced with histopathological assessment - for more information on the ICE test and histopathology, click here), as well as historical in vivo studies. All studies have been assessed for quality and reliability (Klimisch scoring) and study summaries are available for each test report.

An overview of the DetNet structure is illustrated below:

Flowchart of the DetNet structure showing how the database with toxicological data connects through a secured IT tool to expert pools for evaluation and classification, with input from the scientific advisory panel and network management, and providing information to authorities and companies responsible for final classification.